Erythrocyte-Like Mesoporous PDA@CeO2 Nanozyme with Dual Drugs for Periodontitis Treatment.

Periodontitis is a chronic oral inflammatory disease with the characteristic of excess oxidative stress in the inflammatory site, dramatically decreasing the quality of life. Studies show that nanozymes can be ideal candidates for ROS scavenging in periodontitis. Here, we design a multipath anti-inflammatory mesoporous polydopamine@cerium oxide nanobowl (mPDA@CeO2 NB) with multienzyme mimicking properties, which combines the advantages of both CeO2 NP and mPDA NB for synergistically eliminating reactive oxygen species (ROS), including hydroxyl radical (•OH), hydrogen peroxide (H2O2), and superoxide (O2•-). Besides, the erythrocyte-like structure of mNBs makes them a facility for cell uptake, and the mesopores can load both hydrophobic and hydrophilic drugs for combined anti-inflammatory therapy. In vitro and in vivo experiments prove that the combination of CeO2 and mPDA can synergistically achieve multiple complementary ROS eliminations and suppression of ROS-induced inflammation. Moreover, the ROS regulation plus anti-inflammatory drugs in one mPDA@CeO2 NB prevents the progression of periodontitis in a mouse model. Therefore, the design of mPDA@CeO2 NB with these excellent properties provides a therapeutic strategy for inflammatory diseases.

Mesoporous carbon nanoparticles embedded with iron in hydrogen-photothermal synergistic therapy.

We developed a new method to synthesize polyethylene glycol modified ultra small iron embedded in mesoporous carbon nanoparticle (C/Fe-PEG NP) for hydrogen (H2) assisted photothermal synergistic therapy. Herein, we use a simple in-situ reduction method to obtain the C/Fe NP in one-step carbonizing process, which is further modified by the biocompatible polyethylene glycol (PEG) on the surface of C/Fe NP to acquire high stability in physiological solutions. Utilizing the excellent photothermal property from the mesoporous carbon and the controllable H2 release property in the weakly acidic tumor microenvironment by the ultra-small Fe, the obtained C/Fe-PEG NPs can effective kill the cancer cells, meanwhile, protect normal cells without drugs. This selective anti-cancer mechanism of C/Fe-PEG NPs may because the produced H2 selective change the mitochondrial energy metabolism. In vivo results prove that the C/Fe-PEG NPs achieve excellent tumor ablation therapeutic effect and normal tissue protecting ability benefit from the H2-assisted photothermal therapy, promising the use of novel nanomaterials with more safety method for future cancer therapy.

Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma.

Lynch syndrome, an autosomal dominant hereditary disease arising from mutations in mismatch repair genes, is linked to the development of multiple tumor types, notably colorectal cancer, endometrial carcinoma and upper urinary tract urothelial carcinoma. In this study, we present the case of a young patient diagnosed with upper urinary tract urothelial carcinoma, notable for a familial history of diverse malignancies. By employing genetic analysis, we verified the presence of Lynch syndrome within the family and detected novel variants, MSH2 p.A604D and TSC2 p.C738Y, utilizing NGS technology. Subsequently, we conducted validation experiments to assess the pathogenicity of the MSH2 and TSC2 variants. We illustrated that the MSH2 variant can result in diminished MSH2 expression, compromised mismatch repair function, and induce resistance to cisplatin in urothelial carcinoma. Furthermore, we substantiated the promotional impact of the identified TSC2 variant on urothelial carcinoma, encompassing proliferation, invasion, and migration. Significantly, we found that the MSH2 p.A604D variant and TSC2 p.C738Y variant synergistically enhance the promotion of urothelial carcinoma.

In Situ Fe-Substituted Hexacyanoferrate for High-Performance Aqueous Potassium Ion Batteries.

The eco-friendliness, safety, and affordability of aqueous potassium batteries (AKIBs) have made them popular for large-scale energy storage devices. However, the cycling and rate performance of research materials, particularly cobalt hexacyanoferrate, have yet to meet satisfactory standards. Herein, a room-temperature drafted K1.66 Fe0.25 Co0.75 [Fe(CN)6 ]·0.83H2 O (KFCHCF) sample is reported using an in situ substitution strategy. A higher concentration of ferrocyanide ions decreases the water content and increases the potassium content, while citric acid works as a chelating agent and is responsible for Fe-substitution in the KFCHCF sample. The resultant KFCHCF sample exhibits good rate performance, and about 97% and 90.6% of discharge capacity are conserved after 400 and 1000 cycles at 100 and 200 mA g-1 , respectively. The full cell using the KFCHCF cathode and 1,4,5,8-naphthalenetetracarboxylic dianhydride-derived polyimide (PNTCDA) anode maintains ≈74.93% and 74.35% of discharge capacity at 200 mA g-1 and 1000 mA g-1 for 1000 and >10,000 cycles, respectively. Furthermore, ex situ characterizations demonstrate the high reversibility of K-ions and structural stability during the charge-discharge process. Such high performance is attributed to the fast K-ion migration and crystal structure stabilization caused by in situ Fe-substitution in the KFCHCF sample. Other hexacyanoferrates can be synthesized using this method and used in grid-scale storage systems.

Ion Pre-Embedding Engineering of δ-MnO2 for Chemically Self-Charging Aqueous Zinc Ions Batteries.

Aqueous zinc ion batteries (ZIBs), especially those with self-charging properties, have been promisingly developed in recent years. Yet, most inorganic materials feature high redox potential, which limit their development in the self-charging field. To achieve this target, by pre-embedding potassium ions into δ-MnO2 to reduce the energy barrier in oxygen adsorption, the first application of MnO2 in self-charging ZIBs is realized. The design features a facile two-electrode configuration with no excessively complex component to allow for energy storage and conversion. Due to the voltage difference between the oxygen in the air and the discharge products, a redox reaction can be carried out spontaneously to realize the self-charging process. After the chemical self-charging process, the Zn-K0.37 MnO2 ·0.54H2 O/C cell achieves an open circuit voltage of around 1.42 V and a discharge capacity of 201 mAh g-1 , reflecting the promising self-charging capability. Besides, the chemically self-charging ZIBs operate well in multiple modes of constant current charge/discharge/chemical charging. And decent cycling capability can also be achieved at extreme temperatures and high mass loading. This work promotes the development of ZIBs and further broadens the application of inorganic metal oxides in the self-charging systems.

Mussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing.

Uncontrolled hemorrhage caused by trauma can easily lead to death. Efficient and safe hemostatic materials are an urgent and increasing need for hemostatic research. Following a trauma, wound healing is induced by various cellular mechanisms and proteins. Hemostatic biomaterials that can not only halt bleeding quickly but also provide an environment to promote wound healing have been the focus of research in recent years. Mussel-inspired nanoparticle composite hydrogels have been propelling the development of hemostatic materials owing to their unique advantages in adhesion, hemostasis, and bacteriostasis. This review summarizes the hemostatic and antimicrobial fundamentals of polydopamine (PDA)-based nanomaterials and emphasizes current developments in hemorrhage-related PDA nanomaterials. Moreover, it briefly discusses safety concerns and clinical application problems with PDA hemostatic nanomaterials.

Selective Nanoblocker of Cellular Stress Response for Improved Drug-Free Tumor Therapy.

Nanotechnology-based drug-free therapeutic systems using external stimuli can avoid the inherent side effects of drugs and become an attractive therapeutic strategy. However, the cellular stress responses (CSR) are activated encounter with external stimuli, which greatly weaken the efficacy of the drug-free antitumor. Thus, this work proposes a CSR regulation strategy and synthesizes the glucose oxidase (GOx)-modified Cu3 BiS3 nanosheets (CBSG NSs) encapsulated by calcium carbonate (CBSG@CaCO3 ) as the novel drug-free nanoagent. The CBSG@CaCO3 not only cause external stimuli such as energy consumption and oxidative stress damage, but also can destroy the CSR mechanism to guarantee optimal efficacy of starvation-chemodynamic therapy (ST-CDT). In tumor cells, the CaCO3 shell layer of CBSG@CaCO3 is rapidly degraded, releasing the slowly degradable CBSG NSs with NIR-II photothermal properties that accelerate the production of external stimuli under laser irradiation. Meanwhile, CaCO3 can block CSR to disrupt the adaptive viability of cancer cells by inhibiting expression of P27 and NRF2. Importantly, the CSR regulation achieves selective treatment on tumor cells based on the difference in physiological conditions between cancer cells and normal cells. This drug-free cancer therapy with selectivity improves the problem of poor efficacy under the action of CSR, which offers a new avenue in the cancer-related disease treatment.

Ultra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma: a prospective study.

PURPOSE: This single-arm, prospective, exploratory study investigated the effectiveness of ultra-low-dose radiotherapy in the treatment of ocular adnexal lymphoma (OAL). PATIENTS AND METHODS: Patients with pathologically confirmed ocular adnexal low-grade non-Hodgkin lymphoma (predominantly mucosa-associated lymphoid tissue, MALT or follicular lymphoma) were included and treated with ultra-low-dose radiotherapy consisting of 2 successive fractions of 2 Gy at our institution between 2019 and 2021. Disease response was assessed clinically and radiographically within 4 months and at 3 to 6-month intervals after treatment. Data collected included rates of overall response, complete response (CR), partial response (PR), lesion size, and acute/chronic ocular toxic effects. RESULTS: Sixteen patients with median age of 63 years (range 23-86 years) were included in the study. The histological subtypes included MALT (11 patients; 69%); follicular lymphoma (2 patients; 12%); Lymphoid hyperplasia (3 patient, 19%). At a median follow-up time of 15.5 months (range 5.0-30.0 months), the overall response rate was 88%, with a CR rate of 75% (n = 12) and a PR rate of 13% (n = 2). The average lesion area was reduced from 117.9 ± 60.4 mm2 before radiation therapy to 38.7 ± 46.0mm2 at initial evaluation post radiation therapy (P = 0.002, n = 16), and to 8.5 ± 21.2 mm2 (P < 0.001 compared with postoperative lesion area) in patients with response at one year (n = 11). Disease progression was noted in 2 patients (12%). The 1-year rates of local progression-free survivals (LPFS) and overall survival (OS) were 85% and 100%, respectively. No distant relapses were observed in any of the patients. No acute or late toxic effects were noted. CONCLUSION: Ultra-low-dose radiotherapy in patients with OAL is associated with excellent local disease control and long-term survival with no significant acute or late toxicities.

Solid-solution reaction suppresses the Jahn-Teller effect of potassium manganese hexacyanoferrate in potassium-ion batteries.

Potassium manganese hexacyanoferrate (KMnHCF) suffers from poor cycling stability in potassium-ion batteries due to the Jahn-Teller effect, and experiences destabilizing asymmetric expansions and contractions during cycling. Herein, hollow nanospheres consisting of ultrasmall KMnHCF nanocube subunits (KMnHCF-S) are developed by a facile strategy. In situ XRD analysis demonstrates that the traditional phase transition for KMnHCF is replaced by a single-phase solid-solution reaction for KMnHCF-S, which effectively suppresses the Jahn-Teller effect. From DFT calculations, it was found that the calculated reaction energy for K+ extraction in the solid-solution reaction is much lower than that in the phase transition, indicating easier K+ extraction during the solid-solution reaction. KMnHCF-S delivers high capacity, outstanding rate capability, and superior cycling performance. Impressively, the K-ion full cell composed of the KMnHCF-S cathode and graphite anode also displays excellent cycling stability. The solid-solution reaction not only suppresses the Jahn-Teller effect of KMnHCF-S but also provides a strategy to enhance the electrochemical performance of other electrodes which undergo phase transitions.

Enabling high-performance all-solid-state hybrid-ion batteries with a PEO-based electrolyte.

All-solid-state hybrid-ion batteries exhibiting a synergistic Na+/Li+ de/intercalation mechanism were designed and assembled, by using modified PEO-based solid polymer electrolyte, Na2V2(PO4)2O2F cathode, and Li metal anode. The batteries exhibited a high average working voltage of 3.88 V, and an energy density of 432.37 W h kg-1, providing a new avenue for the development of high-safety and low-cost secondary batteries.

Ferroptosis Regulator Modification Patterns and Tumor Microenvironment Immune Infiltration Characterization in Hepatocellular Carcinoma.

Accumulating studies have highlighted the biologic significances of ferroptosis modification in tumor progression, but little is known whether ferroptosis modification patterns have potential roles in tumor microenvironment (TME) immune cell infiltration of hepatocellular carcinoma (HCC). In this study, we evaluated 51 ferroptosis regulators and performed consensus clustering algorithm to determine ferroptosis modification patterns and the ferroptosis related gene signature in HCC. Gene set variation analysis (GSVA) was employed to explore biological molecular variations in distinct ferroptosis modification patterns. Single sample gene set enrichment analysis (ssGSEA) algorithm was performed to quantify the relative infiltration levels of various immune cell subsets. Principal component analysis (PCA) algorithm was used to construct the ferroptosisSig score to quantify ferroptosis modification patterns of individual tumors with immune responses. Three distinct ferroptosis modification patterns were identified. GSVA enrichment analysis indicated that three ferroptosis modification subgroups were enriched in different metabolic pathways. ssGSEA analysis determined that 19 of 24 immune infiltrating cells had significant differences in three distinct ferroptosis patterns. A 91-ferroptosis gene signature was constructed to stratify patients into two ferroptosisSig score groups. Patients in the higher ferroptosisSig score were characterized by significantly prolonged survival time compared with patients in the lower ferroptosisSig score group (p < .0001). An immunotherapy cohort confirmed patients with higher ferroptosisSig score determined significant therapeutic advantages and clinical benefits. Receiver operating characteristic (ROC) curve analysis confirmed the predictive capacity of anti-PD/L1 immunotherapy by ferroptosisSig score. Our study indicated the ferroptosis modification played a significant role in TME heterogeneity and complexity. Evaluating the ferroptosis modification pattern of individual tumor could strengthen our cognition of TME infiltration characteristics and guide more effective clinic immunotherapy strategies.

Active targeted Janus nanoparticles enable anti-angiogenic drug combining chemotherapy agent to prevent postoperative hepatocellular carcinoma recurrence.

Surgery is one of the main effective strategies for the treatment of solid tumors, but high postoperative recurrence is also the main cause of death in current cancer therapy. The prevention of postoperative hepatocellular carcinoma (HCC) recurrence is a clinical problem that needs to be solved urgently. At present, there are still some problems to be solved, such as, how to achieve free drugs to target the site of surgical resection; develop a strategy for the simultaneous administration of multiple drugs to inhibit postoperative recurrence; and provide the appropriate animal model that mimics the process of postoperative HCC recurrence. In this study, we used a facile and reproducible method to successfully prepare amphiphilic Janus nanoparticles (JNPs). In order to improve targeting of the JNPs to residual HCC cells after surgery, we modified the side of gold nanorods (GNRs) with lactobionic acid (LA), thus creating LA-JNPs. This provided an active and targeted co-delivery system for hydrophilic and hydrophobic drugs in separate rooms, thus avoiding mutual effects. Next, we established two models to simulate postoperative HCC recurrence: a subcutaneous postoperative recurrence model based on patient-derived tumor xenograft (PDX) tissues and a postoperative recurrence model of orthotopic HCC. By applying these models, the enhanced permeability and retention effect (EPR) based tumor targeting and LA based active targeting can jointly promote the enrichment and uptake of JNPs at tumor site. LA-JNPs represented an efficient targeting system for the co-delivery of Sorafenib/Doxorubicin with an optimized anti-recurrence effect and significantly improved the survival of mice during treatment for postoperative recurrence.

Designed formation of Prussian Blue/CuS Janus nanostructure with enhanced NIR-I and NIR-II dual window response for tumor thermotherapy.

Designing photothermal transducing agents (PTAs) with enhanced photothermal conversion efficiency (PCE) holds essential importance for photothermal tumor eradication applications. Currently, it is an effective way to improve the photothermal efficiency by designing the energy level transition leading to the enhancement of UV absorption. To address the challenge, we develop novel Prussian blue@polyacrylic acid/copper sulfide Janus nanoparticles (PB@PAA/CuS JNPs) via selective coating of PAA nano-hemisphere on one of the surfaces of PB NPs followed by the further formation of CuS on the PAA template. The experiments show that the energy level transition occurs between Janus structure. Besides, it offers enhanced absorption over NIR-I and NIR-II dual windows. The muscle tissue penetration studies suggest that the PB@PAA/CuS JNPs have deeper tissue penetration in the 1064 nm laser irradiation group, indicating their potential for treating deep-tissue-seated tumors. In a word, the unique PB@PAA/CuS JNPs show an enhanced tumor inhibitory effect over the NIR-I and NIR-II dual windows, which will open up new opportunities for improving PTT efficiency by the rational nanostructural design of PTAs.

Precise engineering of acorn-like Janus nanoparticles for cancer theranostics.

The anisotropic Janus nanoparticles (JNPs) provide synergistic effects by concentrating multiple properties on a single carrier. Herein, we reported a novel and simple approach to fabricate acorn-like poly(acrylic acid)-mesoporous calcium phosphate/polydopamine (PAA-mCaP/PDA) JNPs, which were selectively functionalized with methoxy-poly(ethylene glycol)thiol (PEG-SH) on PDA domains to obtain superior stability, while the other mCaP sides served as a storage space and passage for the anti-cancer drug of doxorubicin (DOX). The unique acorn-like PAA-mCaP/PDA-PEG JNPs were utilized as novel theranostic agents for photoacoustic (PA) imaging-guided synergistic cancer chemo-phototherapy. More importantly, this synthetic strategy can be applied to synthesize various mesoporous Janus nanocarriers, paving the way toward designed synthesis of acorn-like JNPs in nanomedicine, biosensing and catalysis. STATEMENT OF SIGNIFICANCE: The distinct acorn-like poly(acrylic acid)-mesoporous calcium phosphate/polydopamine Janus nanoparticles (PAA-mCaP/PDA JNPs) with a spherical-shaped PAA-mCaP core and PDA half-shell were fabricated for the first time. To achieve superior stability, the acorn-like PAA-mCaP/PDA JNPs were selectively functionalized with methoxy-poly(ethylene glycol)thiol (PEG-SH) on PDA domains to obtain acorn-like PAA-mCaP/PDA-PEG JNPs. The resultant acorn-like PAA-mCaP/PDA-PEG JNPs own an excellent biocompatibility, high drug-loading contents, good photothermal conversion efficiency, photoacoustic (PA) imaging capacity and pH/NIR dual-responsive properties, enabling the acorn-like JNPs to be applied for PA imaging-guided synergistic cancer chemo-phototherapy. More importantly, the synthetic approach could be extended to prepare acorn-like mesoporous inorganic substances/PDA JNPs for specific applications.

Expediting the Conversion of Li2S2 to Li2S Enables High-Performance Li-S Batteries.

The solid-solid conversion of Li2S2 to Li2S is a crucial and rate-controlling step that provides one-half of the theoretical capacity of lithium-sulfur (Li-S) batteries. The catalysts in the Li-S batteries are often useless in the solid-solid conversion due to the poor contact interfaces between solid catalysts and insoluble solid Li2S2. Considering that ultrafine nanostructured materials have the properties of quantum size effects and unconventional reactivities, we design and synthesize for the pomegranate-like sulfur nanoclusters@nitrogen-doped carbon@nitrogen-doped carbon nanospheres (S@N-C@N-C NSs) with a seed-pulp-peel nanostructure. The ultrafine S@N-C subunits (diameter ≈5 nm) and effects of a spatial structure perfectly realize the rapid conversion of ultrafine Li2S2 to Li2S. The S@N-C@N-C seed-pulp-peel NS cathodes exhibit excellent sulfur utilization, superb rate performance (760 mAh g-1 at 10.0 C), and an ultralow capacity decay rate of about 0.016% per cycle over 1000 cycles at 4.0 C. The proposed strategy based on ultrafine nanostructured materials can also inform material engineering in related energy storage and conversion fields.

Maximized Schottky Effect: The Ultrafine V2 O3 /Ni Heterojunctions Repeatedly Arranging on Monolayer Nanosheets for Efficient and Stable Water-to-Hydrogen Conversion.

The Mott-Schottky heterojunction formed at the interface of ultrafine metallic Ni and semiconducting V2 O3 nanoparticles is constructed, and the heterojunctions are "knitted" into the tulle-like monolayer nanosheets on nickel foam (NF). The greatly reduced particle sizes of both Ni and V2 O3 on the Mott-Schottky heterojunction highly enhance the number of Schottky heterojunctions per unit area of the materials. Moreover, arranging the heterojunctions into the monolayer nanosheets makes the heterojunctions repeat and expose to the electrolyte sufficiently. The Schottky heterojunctions are like countless self-powered charge transfer workstations embedded in the tulle-like monolayer nanosheets, promoting maximum of the materials to participate into the electron transfer and become catalytic active sites. In addition, the tulle-like monolayer nanosheet structure can assist in pumping liquid phase electrolyte to the surface of catalysts, owing to the capillary force. The V2 O3 /Ni/NF Mott-Schottky catalyst exhibits excellent hydrogen evolution reaction (HER) performance with a low η10 of 54 mV and needs -107 mV to get the current density of -100 mA cm-2 . Furthermore, V2 O3 /Ni/NF Schottky electrocatalyst exhibits excellent urea oxidation reaction activity: 1.40, 1.51, and 1.61 V versus reversible hydrogen electrode (RHE) voltage are required to reach a current density of 100, 500, and 1000 mA cm-2 , respectively.

Amphiphilic Janus nanoparticles for imaging-guided synergistic chemo-photothermal hepatocellular carcinoma therapy in the second near-infrared window.

Hepatocellular carcinoma (HCC) is one of the most common and deadly malignant tumors worldwide. With unsatisfactory effects of traditional systematic chemotherapy for HCC owing to its drug resistance, novel therapeutic strategies based on nanomaterials for HCC treatments are promising solutions. To solve the challenges of nanoparticles (NPs)-based drug delivery systems for potential clinical applications, we designed water soluble amphiphilic oleic acid-NaYF4:Yb,Er/polydopamine Au nanoflower Janus NPs (OA-UCNPs/PDA-AuF JNPs) with discrete multi compartment nanostructures as dual-drug delivery systems (DDDSs). This unique nanostructure meets the requirements for containing hydrophobic hydroxycamptothecin/hydrophilic doxorubicin in divided spaces and releasing each drug from non-interfering channels under pH/near-infrared (NIR) dual-stimuli. The amphiphilic DDDSs were utilized to eradicate the tumor burden on a high-fidelity HCC model of a patient-derived xenograft (PDX), and represented an efficient strategy for defeating HCC using multi-modal imaging-guided dual-drug chemo-photothermal therapy in the second NIR window. In addition, the potential mechanisms of action for the DDDSs were evaluated.

An EPR-independent therapeutic strategy: Cancer cell-mediated dual-drug delivery depot for diagnostics and prevention of hepatocellular carcinoma metastasis.

Motivated by the "self-seeding" of the cancer cells, the EPR-independent nanoparticles (NPs)-based therapeutic strategy have been explored to prevent hepatocellular carcinoma metastasis in this paper, the mechanism of anti-metastasis of the NPs was also evaluated. We firstly have established an aggressive whole-body spreading orthotopic LM3 tumour model closing to actual cases of human patients and the synthesized Trojan Horse-like amphiphilic nanobowls have been engineered with dual drugs with completely different pharmacokinetic profiles for cancer cell-mediated anti-metastasis therapy. These Trojan Horse-like nanobowls can serve as dual-drug delivery depots for site-specific pH/NIR dual-stimuli drug release with effectively suppressed primary tumor growth and metastases. Furthermore, the multi-mode UCL/MR/CT imaging is competent for providing comprehensive and valuable information for evaluating and adjusting the treatment. The employ of cancer cell-mediated anti-metastasis therapeutic strategy delivering drugs into metastatic cells to defeat tumor metastases provides directions in the fields of anti-metastasis therapy.

in situ engineered ultrafine NiS2-ZnS heterostructures in micro-mesoporous carbon spheres accelerating polysulfide redox kinetics for high-performance lithium-sulfur batteries.

Host materials that can physically confine and chemically adsorb/catalyze lithium polysulfides (LiPSs) are currently receiving intensive research interest for developing lithium-sulfur (Li-S) batteries. Herein, a novel host material made of micro-mesoporous carbon nanospheres (MMC NSs) with well-dispersed ultrafine NiS2-ZnS (uNiS2-ZnS) heterostructures is synthesized for the first time via a simple in situ sulfuration process. The uNiS2-ZnS/MMC materials achieve the synergistic effect of physical confinement and the efficient chemical adsorption/catalysis of LiPSs through a micro-mesoporous structure and well-dispersed uNiS2-ZnS heterostructures. In addition, compared with bulk heterostructured materials, the uNiS2-ZnS heterostructures greatly enhance the adsorption and catalytic ability toward LiPSs because the catalysis interface effect and naturally formed in-plane interfaces can be magnified by the ultrafine dispersed nanoparticles. As a result, the prepared uNiS2-ZnS/MMC-S cathodes exhibit outstanding rate capacity (675.5 mA h g-1 at 5.0C) and cyclic stability (710.5 mA h g-1 at 1.0C after 1000 cycles with a low capacity decay of 0.033% per cycle). This work provides a certain reference for the application of heterostructured materials in Li-S batteries.